Active Learning for Developing Personalized Treatment
Kun Deng, Joelle Pineau, Susan Murphy
The personalization of treatment via bio-markers and other risk categories has drawn increasing interest among clinical scientists. Personalized treatment strategies can be learned using data from clinical trials, but such trials are very costly to run. This paper explores the use of active learning techniques to design more efficient trials, addressing issues such as whom to recruit, at what point in the trial, and which treatment to assign, throughout the duration of the trial. We propose a minimax bandit model with two different optimization criteria, and discuss the computational challenges and issues pertaining to this approach. We evaluate our active learning policies using both simulated data, and data modeled after a clinical trial for treating depressed individuals, and contrast our methods with other plausible active learning policies.
PDF Link: /papers/11/p161-deng.pdf
AUTHOR = "Kun Deng
and Joelle Pineau and Susan Murphy",
TITLE = "Active Learning for Developing Personalized Treatment",
BOOKTITLE = "Proceedings of the Twenty-Seventh Conference Annual Conference on Uncertainty in Artificial Intelligence (UAI-11)",
PUBLISHER = "AUAI Press",
ADDRESS = "Corvallis, Oregon",
YEAR = "2011",
PAGES = "161--168"